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KMID : 1145520170030020080
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Journal of Radiopharmaceuticals and Molecular Probes
2017 Volume.3 No. 2 p.80 ~ p.84
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Preclinical application of 188Re-Tin colloid for treatment of mouse tumor model with peritoneal effusion
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Jin Yong-Nan
Lee Yong-Jin
Kim Young-Joo
Lee Yun-Sang
Jeong Jae-Min
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Abstract
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Re-188 is an excellent and practical radioisotope produced by W-188/Re-188-generator for therapy. We prepared Re-188-tin colloid for therapy of various diseases and tried to treat peritoneal effusion in animal model. Sarcoma-180 cells were injected into ICR mice to induce peritoneal effusion and the mice were grown for 3 d. Re-188-tin colloids (0.25, 0.5, and 1 mCi/mL per 30 g body weight) were injected into the mice and the mice were grown for 90 d. Planar gamma scintigraphy showed even distribution of Re-188-tin colloid radioactivity. Bax expression was found to be dose dependent to Re-188-tin colloid. Normal saline treated group showed the shortest survival time. Among the treated groups, 0.5 mCi dose group showed the longest survival time. In conclusion, Re-188-tin colloid was prepared successfully and showed the feasibility to use as a peritoneal effusion treatment in mice.
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KEYWORD
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Re-188-tin colloid, peritoneal effusion, radionuclide therapy
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